Saturday, January 4, 2020
The Potential Benefits Of Adjuvant Therapy - 3460 Words
. In addition to patient perspectives on their treatment options and findings from a brief GA, a further consideration in estimating potential benefits of adjuvant therapy is the patientââ¬â¢s estimated life expectancy, to determine whether they are likely to live long enough to benefit from the treatment. Chronologic age is an integral component of such estimates; however, it is by no means a sufficient consideration. As our two clinical cases illustrate, two 70 year old breast cancer patients can have very different underlying health, physical activity, and social support systems and require a treatment approach that reflects these differences (Figure 1). It can be particularly challenging for physicians to estimate the life expectancy of their patients, especially for patients in advanced stages of cancer [35]. Fortunately, several tools are available to aid in the estimation of life expectancy in a variety of different patient populations (e.g. community dwelling or nursing ho me) and life expectancy time frame [36]. Many of these tools are available in an online calculator format on the ââ¬Å"ePrognosisâ⬠website (www.eprognosis.com). For example the Lee- Schonberg index intakes into account the patientââ¬â¢s age, gender, body mass index, comorbidities, cigarette smoking, physical activity, previous hospitalizations, and limitations in activities of daily living due to physical, mental, emotional or cognitive problems to estimates the patientââ¬â¢s life expectancy [37-40]. None of theseShow MoreRelatedWhat Is Potential Therapeutic Targets?981 Words à |à 4 PagesTherefore, a cancer that involves a mutation in these BRAC1 and BRAC2 genes (BRCAness) can be effectively treated with PARP1 inhibitors, which may represent very efficient therapies for TNBC because of the high sensitivity of these tumours to the inhibitor and moreimportantly, it is devoid of harmful effects on the remaining healthy cells. This contrasts with conventional chemothera pies, which are highly toxic to all cells and can provoke DNA damage in healthy cells that may further lead to secondaryRead MoreGenetic Testing Services Under Ms. Gelch Essay1143 Words à |à 5 Pagesstates: ââ¬Å"When claim number 201512106349125 (Genomic Health Inc.) was initially processed, it was denied as services that are experimental/investigational are not a covered benefit. The Oncotype DX colon cancer assay procedure is a genetic test. Ms. Gelch s policy specifically excludes coverage for genetic testing. There is no benefit available for genetic testing services under Ms. Gelch s policy.â⬠There is a letter from Patrick Jensen at Genomic Health, Inc., dated 08/05/2016, that states: ââ¬Å"Ms.Read MoreComplications Of Cancer And Treatments996 Words à |à 4 Pages(breathlessness), and metastasis (cancer that spreads) (Mayo Clinic - Complications, 2016). Pain is one of the main physical complications, as the nerves surrounding the tissues feel the pressure due to growing tumor. Pain medications and alternate therapies like massage, yoga, and acupuncture can help patients to cope up with the pain (Mayo Clinic - Complications, 2016). Fatigue can be caused by the side effects of treatments as well and physical and mental distress. Fatigue can be managed through balancedRead MorePIK3C Case Study1100 Words à |à 5 Pagesamplification. Other studies have explored whether HER2 gene amplification has a predictive role in predicting response to anti-EGFR therapy, but results have been contradictory. Some researchers have shown that HER2 gene amplification was positively correlated with resistance to cetuximab or panià ¬tumumab with poor PFS and a trend towards a worse OS (Barbara et al. 2012). Anti-HER2 therapy is used successfully in CRC preclinical trials and have demonstrated that combined EGFR and HER2 inhibition can initiateRead MoreAssessment Of Chronic Pain1329 Words à |à 6 Pagesto achieve steady blood levels, and desired effects. To begin the treatment of chronic pain, weighing the cost of risks and benefits suggests that beginning with non-NSAIDS and working up to opioids is the best way to proceed. Research has suggested that acetaminophen should be the preferred treatment for older patients. (Reid, 2015) The only adverse side effect is potential hepatotoxicity. However, acetaminophen did not improve physical function or stiffness when tested with a placebo group. (ReidRead MoreA Brief Note On The Mammalian Target Of Rapamycin ( Mtor )1489 Words à |à 6 Pagesversus combination tamoxifen and everolimus.[23] The combination treatment was associated with higher clinical benefit rate CBR (42% vs 61%; P =.045), and time to progression (TTP) (4.5 vs 8.6 months; hazard ratio [HR] =0.54; 95% confidence interval [CI], 0.36ââ¬â0.81; P = .002). When patients were stratified based on primary hormone resistance, defined as relapse during adjuvant AI therapy or progression within 6 months of AI treatment in the metastatic setting, or secondary hormone resistance, definedRead MorePatients with Rheumatoid Arthritis and Emotion Regulation Therapy694 Words à |à 3 PagesZautra et al. (2003) examined emotion regulation intervention against cognitive-behavioural therapy and a control condition. Patients with rheumatoid arthritis were provided with mindfullness and emotion regulation therapy (teaching skills to increase awareness, acceptance, and management of negative emotions, CBT for pain management, or health education (for control). Results showed that CBT outperformed mindfulness, but emotion regulation improved pain control, especially for patients with a historyRead MoreModern Medicine Must Not Be Possible Without The Discovery Of Antibiot ics1472 Words à |à 6 Pagesor counterfeit medication being distributed and people would receive effective, more affordable treatments. Making antibiotics available after diagnosis and only by prescription, would help to decrease misuse and increase patient education about benefits and adverse effects of antibiotics (Laxminarayan et al., 2013). Even though some uses of antibiotics are highly regulated and carefully considered, they can still play a role in resistance. Prophylactic antibiotics make life saving proceduresRead MoreVaccine : Chromium Release Assay For Measure Cd4 +1476 Words à |à 6 Pagesproliferation and ELISPOT to measure B cell responses. Tumour regression will be looked for using MRI techniques and visually on the skin. In all phases of clinical trials, patients that can no longer benefit from approved treatments will be used. Stage 3 and 4 patients only will be used due to potential side effects. Patients that do not respond to treatment after 6 months will be removed from the program. Patients that do respond will participate in the trials until death and will be monitored everyRead MoreLipase Inhibitor : Causes And Adverse Effects1576 Words à |à 7 Pagesmg dose under prescription) and in Alli (Orlistat 60 mg dose over the counter). Dr Sidney Wolfe, Director of Public Citizen s Health Research Grou p, declared to the press that, These drugs have the potential to cause significant damage to multiple critical organs, yet they provide meager benefits in reducing weight loss in obese and overweight patients. According to this group, Orlistat should be banned because of increasing evidence that it causes liver damage, kidney stones and pancreatitis
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